Proline Precursors to Sustain Mammalian Collagen Synthesis
نویسندگان
چکیده
منابع مشابه
Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing.
Wound healing is a complex process marked by highly coordinated immune fluxes into an area of tissue injury; these are required for re-establishment of normal tissue integrity. Along with this cascade of cellular players, wound healing also requires coordinated flux through a number of biochemical pathways, leading to synthesis of collagen and recycling or removal of damaged tissues. The availa...
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Barley (Hordeum vulgare L. var. Prior) leaves converted more (14)C-glutamic acid to free proline when water-stressed than when turgid; neither decreased protein synthesis nor isotope trapping by the enlarged free proline pools found in wilted tissue seemed to account for the result. This apparent stimulation of proline biosynthesis in wilted leaves was not observed when radioactive ornithine or...
متن کاملProline metabolism and cancer: emerging links to glutamine and collagen
PURPOSE OF REVIEW Proline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a related amino acid, is considered second in importance only to glucose as a substrate for tumors. But proline and glutamine are interconvertible and linked in their metabolism. In animals, proline and glutamine have specific regulatory functi...
متن کاملConversion of proline to hydroxyproline and its incorporation into collagen.
Most, if not all, of the hydroxyproline in collagen appears to be derived from proline (1, 2). It has been proposed by several investigators (2-7), on indirect evidence, that it is a bound form of proline which is hydroxylated and incorporated into collagen. Recent data (8-11) indicate an analogous situation in the hydroxylation of lysine and its incorporation into collagen. The type of compoun...
متن کاملProline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors.
PEP and aldolase mimicry is the key for a direct organocatalytic entry to precursors of ulosonic acids, biomolecules of enormous importance in biology, chemistry and medicine; in the key aldol reaction the dimethylacetal of pyruvic aldehyde is used as phosphoenolpyruvate (PEP) equivalent and the amino acid proline functions as an organocatalyst, imitating the enzyme.
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2008
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/138.10.2021s